Posts Tagged ‘ABCC11’
Body Odor / ABCC11
There are two kinds of sweat glands: eccrine sweat glands, which are found throughout the skin, and apocrine sweat glands, which are found in the armpits and groin. Eccrine sweat glands produce sweat that is mostly water and salt, and it does not contribute very much to body odor. Apocrine sweat contains proteins and lipids; when bacteria on the skin metabolize apocrine sweat, they produce body odor. The earwax glands (ceruminous glands) are a form of apocrine gland. (…) Some people have earwax that is wet, sticky and yellow or brown; other people’s earwax is dry, crumbly and grayish. Variation at a single gene determines which kind of earwax you have; the allele for wet earwax is dominant over the allele for dry earwax. The allele for dry earwax appears to have originated by mutation in northeastern Asia about 2,000 generations ago, then spread outwards because it was favored by natural selection. It is very common in eastern Asia, becomes much less common towards Europe, and is rare in Africa. Earwax type is not used very often to illustrate basic genetics, but unlike most human characters that are used (tongue rolling, attached earlobes, etc.), it really is controlled by a single gene with two alleles. . (…)
MYTHS OF HUMAN GENETICS by JOHN H. MCDONALD
(retrieved 20.01.2013 at http://www.google.de/url?sa=t&rct=j&q=myths%20of%20human%20genetics&source=web&cd=14&cad=rja&ved=0CEcQFjADOAo&url=http%3A%2F%2Fwww.bio-logisch-nrw.de%2FMyths_of_Human_Genetics__Tongue_Rolling.pdf&ei=wib8UOezFMnYtAaFuYDQAg&usg=AFQjCNFEZd0CAl1L9hrf5_JZmjyAs)
Apocrine Gland Secretion and Body Odor
(…) Martin et al. (2010) performed chemical analysis of axillary sweat samples from 25 individuals with different ABCC11 538G-A genotypes, including 18 Asian participants (11 AA homozygotes, 5 AG heterozygotes, and 2 GG homozygotes) and 7 Caucasian participants (2 AG heterozygotes and 5 GG homozygotes). Levels of 3 glutamine conjugates that are precursors for key body odorants were below detection limits in all participants with the AA genotype but were present in all AG and GG individuals, indicating that ABCC11 is essential for secretion of amino-acid conjugates of relevant axillary odors.
Mapping of Apocrine Gland Secretion
By a functional assay, Yoshiura et al. (2006) determined that cells with allele A showed a lower excretory activity for cGMP than those with allele G. The allele A frequency showed a north-south and east-west downward geographic gradient; worldwide, it was highest in Chinese and Koreans, and a common dry-type haplotype was retained among various ethnic populations. These results suggested that the allele A arose in northeast Asia and thereafter spread through the world. The 538G-A SNP was the first example of DNA polymorphism determining a visible genetic trait.(…)
(both retrieved 21.02.2015 at http://www.omim.org/entry/117800)
World Overview ABCC11
(retrieved 20.01.2013 at http://www.google.de/url?sa=t&rct=j&q=das%20ohrenschmalz%20als%20rassenmerkmal%20und%20der%20rassengeruch&source=web&cd=11&ved=0CDAQFjAAOAo&url=http%3A%2F%2Fge.tt%2Fapi%2F1%2Ffiles%2F50GjGkI%2F0%2Fblob%3Fdownload&ei=FK77ULKmLo_otQaVvoCgBg&usg=AFQjCNEG–tL)
Human Olfactory Communication
Nonhuman animals communicate their emotional states through changes in body odor. The study reported here suggests that this may be the same for humans. (…) The finding suggests that there is information in human body odors indicative of emotional state. This finding introduces new complexity in how humans perceive and interact. (…)
Human Olfactory Communication of Emotion by Chen D. and Haviland-Jones J.
(retrieved 21.05.2015 at http://www.ncbi.nlm.nih.gov/pubmed/11153847)
(retrieved 21.05.2015 at http://www.google.de/url?sa=t&rct=j&q=&esrc=s&source=web&cd=7&cad=rja&uact=8&ved=0CFYQFjAG&url=http%3A%2F%2Fwww.rci.rutgers.edu%2F~baljones%2FHuman%2520Olfactory.pdf&ei=FrJdVeCFH8yVsgHs5oCgBg&usg=AFQjCNEZZU3iIyp2aNjbNP3SilgIbEpKqg&bvm=bv.93756505,d.bGg)
Genetics, Cultures and Happiness / 5-HTTLPR
Joan Chiao and Katherine Blisinsky took a research on the worldwide spreading of the 5-HTTLPR – gene, which is identified as responsible for the mood (anxiety and mood disorder) of it`s carrier by transporting serotonin. It was published from the Royal Society Publishing.
Using Hofstede`s model of cultural indices/dimensions to define cultures into individualistic and collectivistic, they crossed these data with the spreading of 5-HTTLPR.
(…) Here, we demonstrate for the first time a robust association between cultural values of individualism–collectivism and allelic frequency of the serotonin transporter gene, controlling for associated economic and disease factors. (…) Critically, our results further indicate that greater population frequency of S allele carriers is associated with decreased prevalence of anxiety and mood disorders due to increased cultural collectivism. (…)
Results from correlation analysis between Hofstede’s individualism–collectivism index (reverse scored) and frequency of S allele carriers of the 5-HTTLPR across 29 nations. Collectivist nations showed higher prevalence of S allele carriers (r(29) = 0.70, p < 0.0001).
Geographical coincidence between serotonin transporter gene diversity and cultural traits of individualism–collectivism across countries. Colour maps include all available published data for each variable of interest. Grey areas indicate geographical regions where no published data are available. (a ) Hofstede Colour map of frequency distribution of IND-COL from Hofstede (2001). (b) 5-HTTLPR Colour map of frequency distribution of S alleles of 5-HTTLPR. (c) anxiety Colour map of frequency of global prevalence of anxiety. (d) mood disorders Colour map of frequency of global prevalence of mood disorders. Yellow to red colour bar indicates low to high prevalence.
(Chiao, J.Y. & Blizinsky, K.D. 2009 Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene. Proc. R. Soc. B (doi: 10.1098/rspb.2009.1650)
(retrieved 20.05.2015 at http://rspb.royalsocietypublishing.org/content/277/1681/529.full)
Background Info: World`s Haplogroups
This Map of Haplogroups (J.D. McDonald) shows the distribution of certain genetic characteristics. It is widely used for genealogical research because certain cell structures are inherited matrilinear or patrilinear. Click here to download from the the University of Illinois/School of Chemical Sciences. You can also download the full pdf here.
(retrieved 20.05.2015 at http://www.scs.uiuc.edu/%7Emcdonald/WorldHaplogroupsMaps.pdf)
Happiness and Income
From R.Inglehart and H-D.Klingemann, “Genes, Culture and Happiness,” MIT Press, 2000.Check out for more at http://www.worldvaluessurvey.org/
Read a different view on the categories “Cultures and Genes” and “Culture influences Brain” or view the World’s Map of Happiness.